import data and make a list audience

In a workflow create a load activity to load the file, then do a reconcile to a profile, and finally save that to an audience.  Then the audience can be used in an email.

Hi @stine2,

If you have already created file type audience follow this documentation to reconcile file type audience with existing profile db.

https://experienceleague.adobe.com/docs/campaign-standard/using/managing-processes-and-data/workflow-use-case/data-management/reconcile-file-audience-with-database.html?lang=en

or else while importing data reconcile with profile resource that can be used as targets. Take a look at this documentation,

https://experienceleague.adobe.com/docs/campaign-standard/using/managing-processes-and-data/workflow-use-case/data-management/data-update-reconciliation.html?lang=en

Thanks!