Thanks, John & Kristen.
Yes, the roles and Workspaces is checked, however the API only check box will not do anything. I'm not able to check it. I've had another user try checking it as well and nothing happens when they try to check the box. Both of us have Admin access.
I would try recreating the API user. Sometimes they can seem a little buggy after the API functionality gets upgraded. If that doesn't work, I'm kind of out of ideas, so I think you'd need to reach out to support.